Short Answer 
The key differences between Ibuprofen 800mg and 400mg are their dosage and formulation, with the former offering more effective pain relief and easier digestion due to its enteric coating. Ibuprofen 800mg typically has milder side effects compared to Ibuprofen 400mg, which may cause more gastrointestinal discomfort and nausea.
Step 1: Understand Dosage and Formulation
The primary difference between the two drugs lies in their dosage and how they are formulated. The Ibuprofen 800mg is a higher dose typically designed for more effective pain relief, while Ibuprofen 400mg is a standard dose. Each formulation can affect how the body processes these medications, playing a critical role in their effectiveness.
Step 2: Consider Digestibility
When it comes to digestibility, dosage matters. Ibuprofen 800mg is coated with an enteric coating, which promotes easier digestion in the stomach and reduces the chance of nausea. In contrast, Ibuprofen 400mg can lead to a higher likelihood of gastrointestinal discomfort or sickness after ingestion.
Step 3: Recognize Potential Side Effects
Both medications can lead to different after effects. The potential side effects of Ibuprofen 800mg are usually less severe, thanks to its digestibility. In contrast, Ibuprofen 400mg carries a higher risk of negative effects, which may include:
- Vomiting
- Upset stomach
- General nausea